The telomere lengthening conundrum - it could be biology

The telomere lengthening conundrum – it could be biology

Longitudinal studies of human leucocyte telomere length often report a percentage of individuals whose telomeres appear to lengthen. However, based on theoretical considerations and empirical data, Steenstrup et al. (Nucleic Acids Research, 2013, vol 41(13): e131) concluded that this lengthening is unlikely to be a real biological phenomenon and is more likely to be an artefact of measurement e...

The telomere lengthening conundrum—artifact or biology?

Recent longitudinal studies of age-dependent leukocyte telomere length (LTL) attrition have reported that variable proportions of individuals experience LTL lengthening. Often, LTL lengthening has been taken at face value, and authors have speculated about the biological causation of this finding. Based on empirical data and theoretical considerations, we show that regardless of the method used...

Could it be Lyme neuroborreliosis?

How the WTO Could Be Improved

AbstractThis paper examines the impasse in the current Doha Development Round negotiations andasks how the rules of the WTO could be changed to facilitate multilateral negotiations andto increase the welfare of the Member countries. It considers possible changes to the methodof negotiation. As examples of rules which are outdated, it considers the rules relating toregional trade agreements and ...

Telomere recombination and alternative telomere lengthening mechanisms.

Telomeres are nucleoprotein structures at the ends of linear chromosomes that protect them from being recognized as DNA double stranded breaks. Telomeres shorten with every cell division and in the absence of the checkpoint mechanisms critical telomere shortening leads to chromosome end fusions and genomic instability. Cancer cells achieve immortality by engaging in one of the two known mechani...